The Loh lab tackles questions at the interface of peripheral neurobiology and metabolism.

Specifically we are interested in the molecular interactions between the autonomic nervous system and organs like fat and the pancreas. Questions that excite us include: what are the molecular drivers of nerve remodeling inside of these organs? What is the composition of junctions between nerves and organs in the periphery?

Our group uses transgenic mouse models, techniques including the imaging of cleared intact organs with light sheet microscopy, molecular profiling technologies such as proximity-labeling based proteomics and RNA sequencing to study nerves inside of organs.

We also have a long standing interest in the development of chemical genetic tools to discover new brain body interactions in vivo.